AOR
Archives of Ophthalmological Research

The Archives of Ophthalmological Research aims to publish issues related to publish articles of the highest scientific and clinical value at an international level, and accepts articles on these topics. The target audience of the journal included specialists and physicians working in ophthalmology, and other health professionals interested in these fields.

eISSN: 3023-6479
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Online Manuscript System

Index
Original Article
Combined evaluation of visual field and optical coherence tomography angiography data in multiple sclerosis patients
Abstract
Aims: To evaluate Humphrey visual field analyzer (HVFA) data and optical coherence tomography angiography (OCT-A) parameters in multiple sclerosis (MS) patients with optic neuritis (ON) attacks.
Methods: 34 eyes of 34 patients with MS diagnosis who had ON attacks were included in the study. After detailed ophthalmoscopic examination, OCT-A and HVFA images were taken. Spearman correlation analysis was used in statistical analysis.
Results: The mean age of the participants was 31.52±10.09 years. In the correlation analysis, a moderate correlation was found between mean deviation (MD) and foveal deep blood flow (DF) (rho=0.52), and a weak correlation was found between MD and foveal superficial blood flow (SF) (rho=0.40) and optic disc head blood flow (ODF) (rho=0.38). A weak negative correlation was found between pattern standard deviation (PSD) and DF (rho=-0.37) and ODF (rho=-0.40).
Conclusion: This study showed that OCTA data were affected in a manner consistent with HVFA data. More practical and quickly applicable OCTA scans may facilitate the estimation of visual field findings in MS patients.

Keywords : Multiple sclerosis, visual field, optic neuritis, optical coherence tomography angiography

Download Article


1. Katz Sand I. Classification, diagnosis, and differential diagnosis of multiple sclerosis. Curr Opin Neurol. 2015;28(3):193-205.
2. Britze J, Frederiksen JL. Optical coherence tomography in multiple sclerosis. Eye (London, England). 2018;32(5):884-888. doi:10.1038/s41433-017-0010-2
3. Lanzillo R, Cennamo G, Criscuolo C, et al. Optical coherence tomography angiography retinal vascular network assessment in multiple sclerosis. Multiple Sclerosis. 2018;24(13):1706-1714. doi:10.1177/ 1352458517729463
4. Naumovska M, Sheikh R, Bengtsson B, Malmsjö M, Hammar B. Visual outcome is similar in optic neuritis patients treated with oral and i.v. high-dose methylprednisolone: a retrospective study on 56 patients. BMC Neurology. 2018;18(1):160. doi:10.1186/s12883-018-1165-6
5. Petzold A, Fraser CL, Abegg M, et al. Diagnosis and classification of optic neuritis. Lancet Neurol. 2022;21(12):1120-1134. doi:10.1016/s1474-4422(22)00200-9
6. Trip SA, Schlottmann PG, Jones SJ, et al. Optic nerve atrophy and retinal nerve fibre layer thinning following optic neuritis: evidence that axonal loss is a substrate of MRI-detected atrophy. Neuroimage. 2006; 31(1):286-293. doi:10.1016/j.neuroimage.2005.11.051
7. Cheng H, Laron M, Schiffman JS, Tang RA, Frishman LJ. The relationship between visual field and retinal nerve fiber layer measurements in patients with multiple sclerosis. Invest Ophthalmol Vis Sci. 2007;48(12):5798-5805.
8. Khalil DH, Said MM, Abdelhakim MASE, Labeeb DM. OCT and visual field changes as useful markers for follow-up of axonal loss in multiple sclerosis in Egyptian patients. Ocul Immunol Inflamm. 2017; 25(3):315-322.
9. Cennamo G, Romano MR, Vecchio EC, et al. Anatomical and functional retinal changes in multiple sclerosis. Eye. 2016;30(3):456-462. doi:10.1038/eye.2015.256
10. Plumb J, McQuaid S, Mirakhur M, Kirk J. Abnormal endothelial tight junctions in active lesions and normal-appearing white matter in multiple sclerosis. Brain Pathol. 2002;12(2):154-169. doi:10.1111/j.1750- 3639.2002.tb00430.x
11. Wang X, Jia Y, Spain R, et al. Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis. Br J Ophthalmol. 2014;98(10):1368-1373. doi:10.1136/bjophthalmol-2013- 304547
12. Ulusoy MO, Horasanlı B, Işık Ulusoy S. Optical coherence tomography angiography findings of multiple sclerosis with or without optic neuritis. Neurol Res. 2020;42(4):319-326. doi:10.1080/01616412.2020. 1726585
13. Farci R, Carta A, Cocco E, Frau J, Fossarello M, Diaz G. Optical coherence tomography angiography in multiple sclerosis: a cross-sectional study. PLoS One. 2020;15(7):e0236090. doi:10.1371/journal.pone.0236090
14. Mohammadi S, Gouravani M, Salehi MA, et al. Optical coherence tomography angiography measurements in multiple sclerosis: a systematic review and meta-analysis. J Neuroinflammation. 2023;20(1): 85. doi:10.1186/s12974-023-02763-4
15. Caprio M, Russo C, Giugliano A, Ragucci M, Mancini M. Vascular disease in patients with multiple sclerosis: a review. J Vasc Med Surg. 2016;4(2):746-753.
16. Akarsu C, Tan FU, Kendi T. Color Doppler imaging in optic neuritis with multiple sclerosis. Graefes Arch Clin Exp Ophthalmol. 2004; 242(12):990-994. doi:10.1007/s00417-004-0948-1
Article available in :
Volume 1, Issue 4, 2024
Page : 65-68
https://doi.org/10.51271/AOR-0018
Article Information
Received : 01 Eyl 2024
Accepted : 22 Eyl 2024
Published : 23 Eki 2024
Corresponding Author :

Selma Meşen: Department of Ophthalmology, Health Practice and Research Hospital, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkiye

[email protected]
Citation : Meşen S, Meşen A, Muzafferzade M. Combined evaluation of visual field and optical coherence tomography angiography data in multiple sclerosis patients . Arch Ophthalmol Res. 2024;1(4):65-68.

Read: 292
Download : 929
Cited: 0
_Footer