AOR
Archives of Ophthalmological Research

The Archives of Ophthalmological Research aims to publish issues related to publish articles of the highest scientific and clinical value at an international level, and accepts articles on these topics. The target audience of the journal included specialists and physicians working in ophthalmology, and other health professionals interested in these fields.

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Original Article
Evaluation of the long-term efficacy of intravitreal bevacizumab in retinopathy of prematurity
Abstract
Aims: To evaluate post-treatment retinal vascularization in infants treated with intravitreal bevacizumab (IVB) for retinopathy of prematurity (ROP).
Methods: This study retrospectively evaluated data from cases treated for Type 1 ROP and AP-ROP between 2021 and 2024, followed by an examination of the birth weeks, birth weights, post-gestational treatment weeks, retinal vascularization periods, recurrence, and additional treatment needs of these cases.
Results: A total of 58 eyes of 30 infants were included in the study. Intravitreal bevacizumab (0.625 mg/0.025 ml) was injected into 58 eyes of 30 cases. The mean birth weight of the cases was 1178±509 grams (500-2790), and their mean gestational age was 28.2±2.7 weeks (23-34). The mean post-gestational week of IVB treatment was 36.6±2.1 (32-39), with a mean follow-up period of 29.5±4.3 weeks (21-37) after treatment. Following treatment, ROP symptoms were observed to largely regress in all cases, with the plus disease also regressing. Additional laser photocoagulation was performed in four eyes of two cases. The mean week for complete retinal vascularization was 61.9±3.5 (55-67).
Conclusion: High rates of regression can be achieved with intravitreal bevacizumab monotherapy in Type 1 ROP and AP-ROP cases. Furthermore, complete retinal vascularization can be attained during long-term follow-up.

Keywords : Retinopathy of prematurity, intravitreal bevacizumab, retinal vascularization

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Article available in :
Volume 2, Issue 1, 2025
Page : 5-8
https://doi.org/10.51271/AOR-0023
Article Information
Received : 03 Kas 2024
Accepted : 28 Kas 2024
Published : 07 Oca 2025
Corresponding Author :

Yasemin Harbalıoğlu: Department of Ophthalmology, Samsun Training and ResearchHospital, Samsun, Turkiye

[email protected]
Citation : Harbalıoğlu Y. Evaluation of the long-term efficacy of intravitreal bevacizumab in retinopathy of prematurity. Arch Ophthalmol Res. 2025;2(1):5-8.

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