AOR
Archives of Ophthalmological Research

The Archives of Ophthalmological Research aims to publish issues related to publish articles of the highest scientific and clinical value at an international level, and accepts articles on these topics. The target audience of the journal included specialists and physicians working in ophthalmology, and other health professionals interested in these fields.

eISSN: 3023-6479
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Case Report
Misdiagnosis and mismanagement in stage 4 best vitelliform macular dystrophy: a case report highlighting the role of multimodal imaging
Abstract
Best vitelliform macular dystrophy (BVMD) is a typically autosomal dominant retinal disorder characterized by accumulationof lipofuscin in the macula, leading to progressive visual impairment. We report the case of a 42-year-old male diagnosedwith stage 4 BVMD (vitelloruptive stage) who was previously mismanaged with multiple intravitreal anti-VEGF injectionsunder the incorrect assumption of exudative pathology. Fundus photography revealed the characteristic “scrambled egg”appearance, while optical coherence tomography and fundus autofluorescence demonstrated hyperreflective subretinaldeposits and hyperautofluorescence without any evidence of fluid accumulation or choroidal neovascularization. Despite theabsence of electrooculography data, the diagnosis was supported by multimodal imaging. This case highlights the importanceof accurate diagnosis and staging of BVMD, and emphasizes the need to avoid unnecessary therapeutic interventions in thenon-exudative stages of the disease.

Keywords : Best vitelliform macular dystrophy, Best disease, Anti-VEGF therapy, Multimodal imaging, Optical coherence tomography, Fundus autofluorescence, Choroidal neovascularization, Misdiagnosis

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Article available in :
Volume 2, Issue 3, 2025
Page : 55-57
https://doi.org/10.51271/AOR-0037
Article Information
Received : 14 Nis 2025
Accepted : 02 Tem 2025
Published : 28 Tem 2025
Corresponding Author :

Emrullah Beyazyıldız: Department of Opthalmology, Faculty of Medicine, Ankara Medipol University, Ankara, Turkiye

[email protected]
Citation : Beyazyıldız E, Çıtırık M, Bingül E, Yüksel E, Teke MY. Misdiagnosis and mismanagement in stage 4 best vitelliform macular dystrophy: a case report highlighting the role of multimodal imaging. Arch Ophthalmol Res. 2025;2(3):55-57.

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